Regulation of IL-2 expression by transcription factor BACH2 in umbilical cord blood CD4+ T cells
نویسندگان
چکیده
منابع مشابه
AKT family and miRNAs expression in IL-2-induced CD4+T cells
Objective(s): Study of non-coding RNAs is considerable to elucidate principal biological questions or design new therapeutic strategies. miRNAs are a group of non-coding RNAs that their functions in PI3K/AKT signaling and apoptosis pathways after T cell activation is not entirely clear. Herein, miRNAs expression and their putative targets in the mentioned pathways were studied in the activated ...
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The reduced expression of nuclear factor of activated T cells-1 (NFAT1) protein in umbilical cord blood (UCB)–derived CD4 T cells and the corresponding reduction in inflammatory cytokine secretion after stimulation in part underlies their phenotypic differences from adult blood (AB) CD4 T cells. This muted response may contribute to the lower incidence and severity of high-grade acute graft-ver...
متن کاملmicroRNA 184 regulates expression of NFAT1 in umbilical cord blood CD4+ T cells.
The reduced expression of nuclear factor of activated T cells-1 (NFAT1) protein in umbilical cord blood (UCB)-derived CD4+ T cells and the corresponding reduction in inflammatory cytokine secretion after stimulation in part underlies their phenotypic differences from adult blood (AB) CD4+ T cells. This muted response may contribute to the lower incidence and severity of high-grade acute graft-v...
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Objective- In the present study we investigated the isolation protocol, population doubling time (PDT) and the expression of a pluripotential gene by RT-PCR analysis of early transcription factor Nanog in caprine umbilical cord (CUC) Wharton's jelly mesenchymal cells (WJMCs). Design- Experimental in vitro study. Animals- Four mix breed goat. Procedures- CUCs were collected from abattoi...
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il-22 is a member of il-10 cytokine family which is believed to play an important role in inflammatory responses. il-22 has similarities with il-10 including conserved sequences with il-10. il-22 receptor is also comprised of two chains known as l-22r1 and l-10r2; supporting the speculation that the two cytokines may have similar effects. the aim of this study was to shed some light on the biol...
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ژورنال
عنوان ژورنال: Leukemia
سال: 2008
ISSN: 0887-6924,1476-5551
DOI: 10.1038/leu.2008.234